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Product Name
Human CD68 (His & Fc Tag) recombinant protein
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Description
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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Protein name
Macrosialin
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Protein short names
CD68; DKFZP686M18236; SCARD1; LAMP4; GP110; MACROSIALIN
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Uniprot ID
P34810
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Gene Name
CD68
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD68 (NP_001242.2) extracellular domain (Met 1-Ser 319) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CD68/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 546 amino acids and has a predicted molecular mass of 59.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CD68/Fc monomer is approximately 110-120 kDa due to glycosylation.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human CD68 / Macrosialin / Gp110 Protein (His & Fc Tag) SDS-PAGE
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