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Product Name
Human PBK/TOPK (His Tag) recombinant protein
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Description
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
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Protein name
Lymphokine-activated killer T-cell-originated protein kinase
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Protein short names
PBK; SPK; 2810434B10RIK; FLJ14385; AW538537; CT84; HEL164; NORI-3; TOPK; D14ERTD732E
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Uniprot ID
V9HWH0
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Gene Name
PBK; TOPK
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the full length of human PBK (NP_060962.2) (Met 1-Val 322) was fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PBK consists of 333 amino acids and predicts a molecular mass of 37 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
No Kinase Activity
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Validations
Human PDK / PDZ binding kinase / TOPK Protein (His Tag) SDS-PAGE
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