LRRK2 Polyclonal Antibody

Cat.#: 160169

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Product Information

  • Product Name
    LRRK2 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to LRRK2
  • Tested applications
    WB, IF
  • Species reactivity
    Human
  • Alternative names
    LRRK2 antibody; AURA17 antibody; DARDARIN antibody; PARK8 antibody; RIPK7 antibody; ROCO2 antibody; leucine rich repeat kinase 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 2355-2527 of human LRRK2 (NP_940980.3).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • Validations

    Immunofluorescence - LRRK2 Polyclonal Antibody

    Immunofluorescence - LRRK2 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using LRRK2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. Plays an important role in recuiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"