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Product Name
LNX1 Polyclonal Antibody
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Description
Polyclonal antibody to LNX1
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Tested applications
IF
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Species reactivity
Human
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Alternative names
LNX1 antibody; LNX antibody; MPDZ antibody; PDZRN2 antibody; ligand of numb-protein X 1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LNX1 (NP_001119800.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IF 1:50 - 1:100
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Validations
Immunofluorescence - LNX1 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using LNX1 antibody . Blue: DAPI for nuclear staining.
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Background
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.; Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"