LIAS antibody

LIAS antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

LIAS Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 42kd

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

HUSSY 01 antibody; LAS antibody; LIAS antibody; Lip syn antibody; LIP1 antibody; Lipoate synthase antibody; Lipoic acid synthase antibody; lipoic acid synthetase antibody; Lipoyl synthase antibody; mitOChondrial antibody

Rabbit IgG

This antibody was obtained by immunization of LIAS recombinant protein (Accession Number: NM_006859). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

LIAS(lipoyl synthase, mitochondrial) is also named as LAS and belongs to the radical SAM superfamily and lipoyl synthase family. It produces alpha-lipoic acid, an antioxidant and an essential cofactor in alpha-ketoacid dehydrogenase complexes, which participate in glucose oxidation and ATP generation(PMID:22021711). The deduced 373-amino acid protein has a calculated molecular mass of about 42 kD. The N-terminal 26 amino acids encode a potential mitochondrial targeting presequence that, upon removal, would result in a deduced mature protein of 347 amino acids with a molecular mass of about 39 kD(PMID:11389890). Defects in LIAS are a cause of pyruvate dehydrogenase lipoic acid synthetase deficiency (PDHLD).