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Product Name
LGR4 antibody
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Description
LGR4 Rabbit Polyclonal antibody. Positive IHC detected in human small intestine tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
G protein coupled receptor 48 antibody; GPR48 antibody; LGR4 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LGR4 recombinant protein (Accession Number: NM_001346432). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112210(LGR4 Antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112210(LGR4 Antibody) at dilution of 1:200 (under 40x lens)
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Background
LGR4, also known as GPR48, is a membrane of the leucine-rich GPCR family. LGR4 is composed of a large NH2-terminal extracellular domain containing 18 LRRs, the seven membrane-spanning segments, and a COOH-terminal intracellular domain. LGR4 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. It has also been shown that LGR4 regulates cyclic AMP/protein kinase A (PKA) signalling. (PMID: 23756652; 17178856; 24212090)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"