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  • N-lactoyl-phenylalanine (Lac-Phe), >99% purity peptide

N-lactoyl-phenylalanine (Lac-Phe), >99% purity peptide

Not For Human Use, Lab Use Only.

Cat.#: 318943

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Product Information

  • Product Name
    N-lactoyl-phenylalanine (Lac-Phe), >99% purity peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Lac-Phe
  • Sequence
    Lac-Phe
  • Length (aa)
    1
  • Peptide Purity (HPLC)
    99.5%
  • Molecular Formula
    C12H15NO4
  • Molecular Weight
    237.25
  • CAS No.
    183241-73-8
  • PubChem CID
    11075454
  • Source
    Synthetic
  • Form
    Powder
  • Description

    N-lactoyl-phenylalanine (Lac-Phe) is a dipeptide conjugate formed from lactate and phenylalanine. It is identified as a blood-borne signaling metabolite whose biosynthesis is catalyzed by the cytosolic enzyme CNDP2 in various cell types, including immune cells, epithelial cells, and mesenchymal stem cells. The production of Lac-Phe is regulated by extracellular lactate levels, and it is secreted into circulation.

    This metabolite exhibits a marked increase in plasma concentration following physical activity across multiple mammalian species, including mice, racehorses, and humans. In animal models, Lac-Phe levels peak immediately after exercise and return to baseline within hours. Its formation represents a biochemical coupling between metabolic state during activity and endocrine signaling.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Li VL, He Y, Contrepois K, et al. An exercise-inducible metabolite that suppresses feeding and obesity. Nature. 2022;606(7915):785-790. doi:10.1038/s41586-022-04828-5
    • Moya-Garzon MD, Wang M, Li VL, et al. A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites. Cell. Published online November 7, 2024. doi:10.1016/j.cell.2024.10.032
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"