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Product Name
KLRG1 antibody
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Description
KLRG1 Rabbit Polyclonal antibody. Positive WB detected in human blood tissue, Raji cells. Positive IHC detected in human breast cancer. Observed molecular weight by Western-blot: 60 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
human; other species not tested.
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Alternative names
KLRG1 antibody; MAFA L antibody; 2F1 antibody; MAFA LIKE antibody; MAFA 2F1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of KLRG1 recombinant protein (Accession Number: NM_001329099). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
Human peripheral blood leukocyte were subjected to SDS PAGE followed by western blot with Catalog No:112111(KLRG1 antibody) at dilution of 1:200
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:112111(KLRG1 antibody) at dilution of 1:50 (under 40x lens)
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Background
KLRG1 (killer cell lectin-like receptor subfamily G, member 1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is expressed by subsets of NK and T cells, existing both as a monomer and as a disulfide-linked homodimer (PMID: 10741410; 19604491). It is considered to be a cell differentiation marker for NK and T cells and is strongly induced by viral and other infections (PMID: 20373518). Through interactions with members of the cadherin family, KLRG1 plays an inhibitory role on NK- and T-cell function (PMID: 19009530; 20373518).
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