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Product Name
KLHL2 Polyclonal Antibody
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Description
Polyclonal antibody to KLHL2
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Tested applications
WB
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Species reactivity
Human
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Alternative names
KLHL2 antibody; ABP-KELCH antibody; MAV antibody; MAYVEN antibody; kelch-like protein 2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic Peptide of human KLHL2
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
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Validations
Western blot - KLHL2 Polyclonal Antibody
Western blot analysis of extracts of 293T cells, using KLHL2 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"