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Product Name
KIR3DL2 Polyclonal Antibody
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Description
Polyclonal antibody to KIR3DL2
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
KIR3DL2 antibody; 3DL2 antibody; CD158K antibody; KIR-3DL2 antibody; NKAT-4 antibody; NKAT4 antibody; NKAT4B antibody; p140 antibody; killer cell immunoglobulin-like receptor 3DL2 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 361-455 of human KIR3DL2 (NP_006728.2).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
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Validations
Western blot - KIR3DL2 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using KIR3DL2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 60s.
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Background
Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"