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Product Name
KCNN4 Polyclonal Antibody
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Description
Polyclonal antibody to KCNN4
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Tested applications
WB
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Species reactivity
Human
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Alternative names
KCNN4 antibody; DHS2 antibody; IK antibody; IK1 antibody; IKCA1 antibody; KCA4 antibody; KCa3.1 antibody; SK4 antibody; hIKCa1 antibody; hKCa4 antibody; hSK4 antibody; potassium calcium-activated channel subfamily N member 4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 288-427 of human KCNN4 (NP_002241.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
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Validations
Western blot - KCNN4 Polyclonal Antibody
Western blot analysis of extracts of 293T cells, using KCNN4 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.
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Background
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"