KCNMA1 Polyclonal Antibody

KCNMA1 Polyclonal Antibody

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• Material Safety Data Sheets (MSDS)

Polyclonal antibody to KCNMA1

WB

Rat

KCNMA1 antibody; BKTM antibody; KCa1.1 antibody; MaxiK antibody; SAKCA antibody; SLO antibody; SLO-ALPHA antibody; SLO1 antibody; bA205K10.1 antibody; hSlo antibody; mSLO1 antibody; calcium-activated potassium channel subunit alpha-1 antibody

Rabbit IgG

Antigen: A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNMA1 (NP_001258447.1).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

WB 1:200 - 1:2000

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).