KAT7 Polyclonal Antibody

Cat.#: 164652

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Product Information

  • Product Name
    KAT7 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to KAT7
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    KAT7 antibody; HBO1 antibody; HBOA antibody; MYST2 antibody; ZC2HC7 antibody; lysine acetyltransferase 7 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 55-193 of human KAT7 (NP_008998.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • Validations

    Western blot - KAT7 Polyclonal Antibody

    Western blot - KAT7 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using KAT7 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.

    Immunofluorescence - KAT7 Polyclonal Antibody

    Immunofluorescence - KAT7 Polyclonal Antibody

    Immunofluorescence analysis of HeLa cells using KAT7 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

  • Background
    Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"