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KANK2 antibody

Cat.#: 111909

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Product Information

  • Product Name
    KANK2 antibody
  • Documents
  • Description
    KANK2 Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in mouse lung tissue, mouse heart tissue, mouse kidney tissue, Transfected HEK-293 cells. Observed molecular weight by Western-blot: 95kd
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    ANKRD25 antibody; DKFZp434N161 antibody; FLJ20004 antibody; KANK2 antibody; KIAA1518 antibody; MXRA3 antibody; SIP antibody; SRC 1 interacting protein antibody; SRC1 interacting protein antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of KANK2 recombinant protein (Accession Number: NM_001379563). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:10-1:100

  • Validations

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:111909(KANK2 antibody) at dilution of 1:800

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:111909(KANK2 antibody) at dilution of 1:800

    Immunofluorescent analysis of HepG2 cells, using KANK2 antibody Catalog No:111909 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

    Immunofluorescent analysis of HepG2 cells, using KANK2 antibody Catalog No:111909 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

  • Background
    Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.
  • References
    • Yasuda K, Zhang H, Loiselle D, Haystead T, Macara IG, Mili S. The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules. The Journal of cell biology. 203(5):737-46. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"