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Product Name
Human KLK8/Kallikrein 8 (His Tag) recombinant protein
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Description
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
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Protein name
Kallikrein-8
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Protein short names
BSP1; NRPN; PRSS19; NP; KLK8; TADG14; UNQ283/PRO322; HNP; KALLIKREIN 8
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Uniprot ID
O60259
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Gene Name
KLK8; NRPN; PRSS19; TADG14; UNQ283/PRO322
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human KLK8 isoform 1 (O60259-1) (Met 1-Gly 260) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human KLK8 consists of 243 amino acids and predictes a molecular mass of 26.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhKLK8 is approximately 36 kDa due to glycosylation.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate BocVPRAMC(Catalog # ES011). The specific activity is > 400pmoles/min/μg
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Validations
Human KLK-8 / Kallikrein-8 Protein (His Tag) SDS-PAGE
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