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Product Name
Jelleine-I peptide (TFA removed)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
PFKLSLHL-NH2
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Sequence
Pro-Phe-Lys-Leu-Ser-Leu-His-Leu-NH2
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Length (aa)
8
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Peptide Purity (HPLC)
99.52%
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Molecular Formula
C47H76N12O9
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Molecular Weight
953.24
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Source
Synthetic
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Form
Powder
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Description
Active against G+ bacteria S. aureus ATCC 6535, S. saprophyticus, B. subtilis CCT 2471 (MIC 10-15 ug/ml), and G- bacteria E. coli CCT 1371 (MIC 2.5 ug/ml), E. cloacae ACCT 23355, K. pneumoniae ACCT 13883, P. aeruginsa ACCT 27853 (MIC 10 ug/ml), and yeast C. albicans (MIC 2.5 ug/ml). Jelleines are produced constitutively by the workers and secreted into Royal Jelly. This peptide can show synergistic killing of Gram-positive bacteria with temporin A or B (Romanelli A et al 2011 Peptides Jan 19. doi: 10.1002/psc.1316). Updated Jan 2011; 7/2014. Jelleine-I has Antibacterial, Antifungal activity. The source of Jelleine-I is honeybees, Apis mellifera.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Fontana R, Mendes MA, De souza BM, et al. Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera). Peptides. 2004;25(6):919-28.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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