ITM2C antibody

ITM2C antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

ITM2C Mouse Monoclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in A431 cells. Observed molecular weight by Western-blot: 35kd

ELISA, WB, IF

Human; other species not tested.

BRICD2C antibody; Cerebral protein 14 antibody; E25 antibody; E25C antibody; integral membrane protein 2C antibody; ITM2C antibody; ITM3 antibody; PSEC0047 antibody; Transmembrane protein BRI3 antibody

Mouse IgG2a

This antibody was obtained by immunization of ITM2C recombinant protein (Accession Number: NM_001012516). Purification method: Caprylic acid/ammonium sulfate precipitation.

Monoclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.