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Product Name
Islet 1 antibody
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Description
Islet 1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human pancreas tissue. Positive WB detected in BxPC-3 cells, HeLa cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 39kd, 45kd
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Tested applications
ELISA, WB, IP, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Isl 1 antibody; ISL LIM homeobox 1 antibody; ISL1 antibody; Islet 1 antibody; ISLET1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Islet 1 recombinant protein (Accession Number: NM_002202). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
BxPC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:111941(ISL1 antibody) at dilution of 1:500
IP Result of anti-Islet 1 (IP:Catalog No:111941, 4ug; Detection:Catalog No:111941 1:500) with HeLa cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using Catalog No:111941(Islet 1 Antibody) at dilution of 1:200 (under 40x lens)
Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using Catalog No:111941(Islet 1 Antibody) at dilution of 1:200 (under 40x lens)
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Background
ISL1 belongs to the LIM homeodomain transcription factor family that binds to the enhancer region of the insulin gene. It plays a pivotal role in cardiogenesis, and lacking ISL1 expression results in growth arrest or displays profound defects in heart development, including atria, ventricle, and the inflow and outflow tracts.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"