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Product Name
INTS7 antibody
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Description
INTS7 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, A431 cells. Positive IF detected in SH-SY5Y cells. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 107kd
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
C1orf73 antibody; DKFZp434B168 antibody; INT7 antibody; integrator complex subunit 7 antibody; INTS7 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of INTS7 recombinant protein (Accession Number: NM_001199811). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:111809(INTS7 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human brain using Catalog No:111809(INTS7 antibody) at dilution of 1:100 (under 40x lens)
Immunofluorescent analysis of SH-SY5Y cells using Catalog No:111809(INTS7 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
INTS7 is a subunit of the integrator complex. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase (PMID: 21659603).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"