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Product Name
Human IL37 / IL1F7 / IL-1H4 recombinant protein
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Description
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
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Protein name
Interleukin-37
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Protein short names
FIL1Z; FIL1(ZETA); IL1H4; FIL1; IL-1RP1; IL1F7; IL-1F7; IL-37; IL-1H; IL-1H4; IL1RP1
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Uniprot ID
Q9NZH6
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Gene Name
IL37; FIL1Z; IL1F7; IL1H4; IL1RP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human IL1F7 isoform A (Q9NZH6-2) (Lys 27-Asp 192) was expressed and purified, with an initial Met.
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Protein Species
Human
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Molecular weight
The recombinant human IL1F7 consisting of 167 amino acids and has a calculated molecular mass of 18.7 kDa.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human IL37 / IL1F7 / IL-1H4 Protein SDS-PAGE
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