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Product Name
Human IL37/FIL1Z/IL1F7/IL1H4/IL1RP1 recombinant protein
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Description
Human Interleukin family 1 Member 7 (IL1F7) is a member of the Interleukin 1 cytokine family. Five alternatively spliced transcript variants encoding distinct isoforms have been reported with distinct expression profiles. The longest IL1F7 transcript, referred to as IL1F7b or IL1F7 isoform 1, encodes a 218 amino acid residues proprotein containing a 45 amino acid propeptide, which is cleaved to generate mature protein. IL1F7b binds to IL18 Rα with low affinity but does not exert any IL18 agonistic or antagonistic effects. IL1F7b also binds interleukin 18 binding protein (IL-18BP), an inhibitory binding protein of interleukin 18 (IL-18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL-18.
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Protein name
Interleukin-37
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Protein short names
FIL1Z; IL1F7; IL1H4; IL1RP1
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Uniprot ID
Q9NZH6.2
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human IL37/FIL1Z/IL1F7/IL1H4/IL1RP1 Lys53-Asp218 is expressed.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human IL37/FIL1Z/IL1F7/IL1H4/IL1RP1 recombinant protein
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