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Product Name
Human IL36B/IL1F8 recombinant protein
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Description
Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.
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Protein name
Interleukin-36 beta
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Uniprot ID
Q9NZH7
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Gene Name
IL36B; IL1F8; IL1H2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human IL36B isofrom 2 (Q9NZH7-2) (Met 1-Glu 157) was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human IL36B consists of 157 amino acids and has a predicted molecular mass of 17.7 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human IL36B / IL1F8 Protein SDS-PAGE
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