Human IL36B/IL1F8 (His Tag) recombinant protein

Cat.#: 503401

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Product Information

  • Product Name
    Human IL36B/IL1F8 (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.
  • Protein name
    Interleukin-36 beta
  • Uniprot ID
    Q9NZH7
  • Gene Name
    IL36B; IL1F8; IL1H2
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of human IL1F8 (NP_775270.1) (Lys 5-Glu 157) was expressed with a polyhistide tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL1F8 consists of 169 amino acids and predicts a molecular mass of 19.3 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human IL36B / IL1F8 Protein (His Tag) SDS-PAGE

    Human IL36B / IL1F8 Protein (His Tag) SDS-PAGE

    Human IL36B / IL1F8 Protein (His Tag) SDS-PAGE

    Human IL36B / IL1F8 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"