Mouse IL36B/IL1F8 recombinant protein

Mouse IL36B/IL1F8 recombinant protein

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Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4(+) T cells and splenocytes.

Interleukin-36 beta

2310043N20RIK; MGC126880; FIL1-(ETA); FIL1; IL1H2; IL-1F8; IL1-ETA; IL36B; FIL1H; FILI-(ETA); IL-1H2; RP23-176J12.1; MGC126882; IL1F8

Q9D6Z6

Il36b; Fil1e; Il1f8

E. coli

A DNA sequence encoding the mouse IL1F8 (Q9D6Z6) (Met 1-Lys 183) was expressed.

Mouse

The recombinant mouse IL1F8 consisting of 183 amino acids and has a calculated molecular mass of 21 kDa as estimated in SDS-PAGE under reducing conditions.

> 96 % as determined by SDS-PAGE