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Product Name
Human WSX-1/IL-27R (Fc Tag) recombinant protein
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Description
Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
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Protein name
Interleukin-27 receptor subunit alpha
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Protein short names
IL27R; TCCR; IL-27RA; WSX1; CRL1; IL27RA; IL-27R; WSX-1; ZCYTOR1
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Uniprot ID
Q6UWB1
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Gene Name
IL27RA; CRL1; TCCR; WSX1; UNQ296/PRO336
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Arg 514) of human IL27R? (NP_004834.1) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL27R?/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 722 amino acids and has a predicted molecular mass of 79 kDa. As a result of glycosylation, rh IL27R?/Fc monomer migrates as an approximately 105-115 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized human IL27 at 20 μg/ml (100 μl/well) can bind human IL27Ra with a linear ranger of 0.064-1.6 μg/ml.
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Validations
Human IL27Ra / TCCR / WSX1 Protein (Fc Tag) SDS-PAGE
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