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Product Name
Human IL-22BP/IL-22RA2 (His & Fc Tag) recombinant protein
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Description
Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
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Protein name
Interleukin-22 receptor subunit alpha-2
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Protein short names
CRF2X; ZCYTOR16; CRF2-10; CRF2-S1; IL-22RA2; MGC150510; MGC150509; IL22RA2; IL-22R-ALPHA-2; IL-22BP
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Uniprot ID
Q969J5
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Gene Name
IL22RA2; UNQ5793/PRO19598/PRO19822
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL22RA2/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 458 amino acids and has a predicted molecular mass of 52.8 kDa. As a result of glycosylation, rh IL22RA2/Fc monomer migrates as an approximately 80-90 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human IL22BP / IL22RA2 Protein (His & Fc Tag) SDS-PAGE
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