Human IL-22BP/IL-22RA2 (His Tag) recombinant protein

Human IL-22BP/IL-22RA2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.

Interleukin-22 receptor subunit alpha-2

MGC150510; CRF2-10; ZCYTOR16; CRF2-S1; IL-22RA2; CRF2X; IL-22BP; IL-22R-ALPHA-2; IL22RA2; MGC150509

Q969J5

IL22RA2; UNQ5793/PRO19598/PRO19822

Human Cells

A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed, fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human IL22RA2 comprises 221 amino acids with a predicted molecular mass of 26.1 kDa. As a result of glycosylation, rh IL22RA2 migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 (Cat:502557), The EC₅₀ of biotinylated IL22 (Cat:502557) is 1.78-4.14 ng/ml.