Human IL-22BP/IL-22RA2 (His Tag) recombinant protein

Cat.#: 503458

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Product Information

  • Product Name
    Human IL-22BP/IL-22RA2 (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.
  • Protein name
    Interleukin-22 receptor subunit alpha-2
  • Protein short names
    MGC150510; CRF2-10; ZCYTOR16; CRF2-S1; IL-22RA2; CRF2X; IL-22BP; IL-22R-ALPHA-2; IL22RA2; MGC150509
  • Uniprot ID
    Q969J5
  • Gene Name
    IL22RA2; UNQ5793/PRO19598/PRO19822
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed, fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human IL22RA2 comprises 221 amino acids with a predicted molecular mass of 26.1 kDa. As a result of glycosylation, rh IL22RA2 migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 (Cat:502557), The EC50 of biotinylated IL22 (Cat:502557) is 1.78-4.14 ng/ml.
  • Validations

    Human IL22BP / IL22RA2 Protein (His Tag) SDS-PAGE

    Human IL22BP / IL22RA2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"