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Product Name
Mouse IL-11 / interleukin 11 recombinant protein
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Description
IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.
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Protein name
Interleukin 11
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Protein short names
IL-11; IL11; ADIPOGENESIS INHIBITORY FACTOR; OPRELVEKIN; AGIF; INTERLEUKIN 11
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Uniprot ID
P47873
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Gene Name
Il11; mCG_21496
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Il11 (NP_032376.1) (Pro22-Leu199) was expressed.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Il11 consists 178 amino acids and predicts a molecular mass of 19.2 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Mouse IL-11 / interleukin 11 Protein
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