Human IL-11 / interleukin 11 recombinant protein
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Protein short names
IL11; ADIPOGENESIS INHIBITORY FACTOR; OPRELVEKIN; AGIF; INTERLEUKIN 11; IL-11
A DNA sequence encoding the mature form of human IL11 (AAH12506.1) (Pro22-Leu199) was expressed.
The recombinant human IL11 consists of 337 amino acids and predicts a molecular mass of 36.2 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
Human IL11 / Interleukin 11 / IL-11 Protein SDS-PAGE
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