Human IFITM3 (Fc Tag) recombinant protein

Human IFITM3 (Fc Tag) recombinant protein

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• Material Safety Data Sheets (MSDS)

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Interferon-induced transmembrane protein 3

FGLS; INTERFERON-INDUCIBLE PROTEIN 15; 1110004C05RIK; 1-8U; INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3; MIL-1; INTERFERON-INDUCIBLE PROTEIN 1-8U; IP15; CDW217; CD225; DSPA2B; IFITM-LIKE PROTEIN 1; FRAGILIS PROTEIN

Q01628

IFITM3

Human Cells

A DNA sequence encoding the human IFITM3 (NP_066362.2) (Met1-His57) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.

Human

The recombinant human IFITM3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 293 amino acids and has a predicted molecular mass of 32.9 kDa. The apparent molecular mass of the monomer is approximately 33-45 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 99 % as determined by SDS-PAGE