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Anti-Fragilis Rabbit antibody

Cat.#: 167353

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Fragilis Rabbit antibody
  • Documents
  • Description
    Fragilis Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human
  • Alternative names
    1-8U; IP15; DSPA2b antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Fragilis
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

    IHC: 1/50

    ICC/IF: 1/50

    FC: 1/20

  • Validations

    Immunohistochemistry of Fragilis in paraffin-embedded Human breast cancer tissue using Fragilis Rabbit pAb at dilution 1/50

    Immunohistochemistry of Fragilis in paraffin-embedded Human breast cancer tissue using Fragilis Rabbit pAb at dilution 1/50

    Immunocytochemistry of Fragilis(green) in Hela cells using Fragilis Rabbit pAb at dilution 1/50, and DAPI(blue)

    Immunocytochemistry of Fragilis(green) in Hela cells using Fragilis Rabbit pAb at dilution 1/50, and DAPI(blue)

    Western blot detection of Fragilis in K562,Hela cell lysates using Fragilis Rabbit pAb(1:1000 diluted).Predicted band size:15kDa.Observed band size:15kDa.

    Western blot detection of Fragilis in K562,Hela cell lysates using Fragilis Rabbit pAb(1:1000 diluted).Predicted band size:15kDa.Observed band size:15kDa.

  • Background
    Swiss-Prot Acc.Q01628.IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"