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Product Name
Integrin beta-1 antibody
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Description
Integrin beta-1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HT-1080 cells. Observed molecular weight by Western-blot: 130 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CD29 antibody; FNRB antibody; GPIIA antibody; Integrin beta 1 antibody; ITB1 antibody; ITGB1 antibody; MDF2 antibody; MSK12 antibody; VLA 4 subunit beta antibody; VLA BETA antibody; VLAB antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Integrin beta-1 recombinant protein (Accession Number: NM_002211). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:111862(ITGB1 antibody) at dilution of 1:300
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Background
Integrin beta-1 (ITGB1), also named as CD29, is a 130 kDa single chain type I glycoprotein that is expressed in a heterodimeric complex with one of six distinct α subunits, comprising the very late activation antigen (VLA) subfamily of adhesion receptors. It is one of the essential surface molecules expressed on human MSC from bone marrow and other sources. The β1 subunit is also broadly expressed on lymphocytes and monocytes, weakly expressed on granulocytes, and not expressed on erythrocytes. These receptors are involved in a variety of cell-cell and cell-matrix interactions.
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References
- Yang SD, Ma L, Gu TX. 17β-Estradiol protects against apoptosis induced by levofloxacin in rat nucleus pulposus cells by upregulating integrin α2β1. Apoptosis : an international journal on programmed cell death. 19(5):789-800. 2014.
- Zeng F, Luo F, Lv S. A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway. Anti-cancer drugs. 25(6):663-72. 2014.
- Liu D, Zhang XX, Wan DY. Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells. Biochemical and biophysical research communications. 446(2):549-54. 2014.
- Geng F, Huang X, Ma M. Hen Egg White Ovomacroglobulin Promotes Fibroblast Migration via Mediating Cell Adhesion and Cytoskeleton. Journal of the science of food and agriculture. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"