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Mouse IGFBP6 / IBP6 (His Tag) recombinant protein

Cat.#: 501970

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Product Information

  • Product Name
    Mouse IGFBP6 / IBP6 (His Tag) recombinant protein
  • Documents
  • Description
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Protein name
    Insulin-like growth factor-binding protein 6
  • Protein short names
    IGFBP-6; IBP6; IGFBP6; IBP-6
  • Uniprot ID
    P47880
  • Gene Name
    Igfbp6; Igfbp-6
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse IGFBP6 (NP_032370.2) (Met 1-Gly 238) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse IGFBP6 consists of 224 amino acids and has a predicted molecular mass of 24 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmIGFBP6 is approximately 30 kDa due to glycosylation.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast adenocarcinoma cells (Karey, K.P. et al. (1988) Cancer Research 48:4083.). The ED50 for this effect is typically 1-4 μg/ml in the presence of 20 ng/mL mouse IGFII.
  • Validations

    Mouse IGFBP6 / IBP-6 Protein (His Tag) SDS-PAGE

    Mouse IGFBP6 / IBP-6 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"