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Product Name
Human ING4 (His Tag) recombinant protein
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Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
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Protein name
Inhibitor of growth protein 4
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Protein short names
MY036; ING1-LIKE PROTEIN; ING4; BRAIN MY036 PROTEIN; CANDIDATE TUMOR SUPPRESSOR P33 ING1 HOMOLOG; D6XRF92; P29ING4; D6WSU147E; INHIBITOR OF GROWTH FAMILY; MEMBER 4; INHIBITOR OF GROWTH PROTEIN 4
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Uniprot ID
Q9UNL4
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Gene Name
ING4; My036
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human ING4 (Q9UNL4-1) (Met1-Lys249) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ING4 consists of 264 amino acids and predicts a molecular mass of 30.4 KDa. It migrates as an approximately 31 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human ING4 Protein (His Tag) SDS-PAGE
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