Mouse Activin A / INHBA (His Tag) recombinant protein

Mouse Activin A / INHBA (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Inhibin beta A chain

FRP; EDF; INHBA; INHIBIN BETA A; ACTIVIN

Q3UY39

Inhba

Human Cells

A DNA sequence encoding the pro form of mouse INHBA (NP_032406.1) (Met 1-Ser 424) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse INHBA comprises 415 amino acids and has a calculated molecular mass of 46.5 kDa. As a result of glycosylation, the apparent molecular mass of rmINHBA is approximately 18 & 43 kDa corresponding to the mature inhibin beta A chain and the pro domain respectively in SDS-PAGE under reducing conditions.

> 88 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized human ACVR2B (Cat:503817) at 10 μg/mL (100 μl/well) can bind biotinylated mouse INHBA-His (Cat:500709), The EC₅₀ of biotinylated mouse INHBA-His (Cat:500709) is 0.161 μg/mL.
3. Immobilized mouse INHBA-his at 10 μg/mL (100 μl/well) can bind human Follistatin Protein, The EC₅₀ of human Follistatin Protein is 0.39 μg/mL.