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Product Name
Human Activin A / INHBA recombinant protein
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Description
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
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Protein name
Inhibin beta A chain
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Uniprot ID
P08476
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Gene Name
INHBA
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding mature form of human INHBA (NP_002183.1) (Gly311-Ser426) was expressed. The mature form sequences of the human, mouse, rat, cynomolgus and rhesus INHBA are identical.
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Protein Species
Human
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Molecular weight
The recombinant human INHBA consists of 116 amino acids and predicts a molecular mass of 13 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Activity
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 4-16ng/mL.
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Validations
Human / Mouse / Rat / Cynomolgus / Rhesus Activin A / INHBA Protein
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"