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Product Name
IMPDH2 antibody
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Description
IMPDH2 Rabbit Polyclonal antibody. Positive IHC detected in human brain. Positive WB detected in A549 cells, K-562 cells, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 56kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
IMPDH2 antibody; IMPDH II antibody; IMPDH 2 antibody; IMPD2 antibody; IMPD 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000884). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111785(IMPDH2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human brain using Catalog No:111785(IMPDH2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:111785(IMPDH2 antibody) at dilution of 1:50 (under 40x lens)
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Background
IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270)This antibody is specific to IMPDH2.
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