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Product Name
IL23A antibody
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Description
IL23A Mouse Monoclonal antibody. Positive IHC detected in human pancreas tissue. Positive WB detected in Transfected HEK-293 cells. Observed molecular weight by Western-blot: 21 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
IL 23 antibody; IL 23 A antibody; IL 23 subunit alpha antibody; IL 23A antibody; IL 23p19 antibody; IL23A antibody; IL23P19 antibody; Interleukin 23 subunit alpha antibody; Interleukin 23 subunit p19 antibody; P19 antibody; SGRF antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of IL23A recombinant protein (Accession Number: NM_016584). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Untransfeted HEK293 cells (left) and IL23A transfected HEK293 cells (right) were subjected to SDS-PAGE followed by western blot with Catalog No:107394 (IL23A monoclonal Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using Catalog No:107394(IL23A Antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using Catalog No:107394(IL23A Antibody) at dilution of 1:50 (under 40x lens)
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Background
IL23A is a subunit of the heterodimeric cytokine interleukin 23 (IL23), which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naïve T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"