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IL13RA2 antibody

Cat.#: 111661

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Product Information

  • Product Name
    IL13RA2 antibody
  • Documents
  • Description
    IL13RA2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue, human gliomas tissue, human ovary tumor tissue. Positive WB detected in rat thymus tissue, HeLa cells, rat liver tissue. Observed molecular weight by Western-blot: 65 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CD213A2 antibody; CT19 antibody; IL 13 receptor subunit alpha 2 antibody; IL 13R antibody; IL 13R alpha 2 antibody; IL 13R subunit alpha 2 antibody; IL 13RA2 antibody; IL13BP antibody; IL13R antibody; IL13RA2 antibody; IL13Ralpha2 antibody; Interleukin 13 binding protein antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of IL13RA2 recombinant protein (Accession Number: NM_000640). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:50-1:500

  • Validations

    rat thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:300

    rat thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:200 (under 10x lens).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:200 (under 40x lens).

    Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using Catalog No:111661(IL13RA2,CD213A2 Antibody) at dilution of 1:200 (under 40x lens).

  • Background
    IL13RA2, also named as IL13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).
  • References
    • Akiyama Y, Komiyama M, Miyata H. Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients. Oncology reports. 31(4):1683-90. 2014.
    • Brøchner CB, Holst CB, Møllgård K. Outer brain barriers in rat and human development. Frontiers in neuroscience. 9:75. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"