IL12B antibody

IL12B antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

IL12B Mouse Monoclonal antibody. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 37 kDa

ELISA, WB

Human, Pig; other species not tested.

CLMF antibody; CLMF p40 antibody; CLMF2 antibody; IL 12 subunit p40 antibody; IL 12B antibody; IL12B antibody; Interleukin 12 subunit beta antibody; NKSF antibody; NKSF2 antibody

Mouse IgG2a

This antibody was obtained by immunization of IL12B recombinant protein (Accession Number: NM_002187). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Interleukin-12 (IL-12), is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit (IL-12A p35) and a 40 kDa subunit (IL-12B p40) that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.