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Product Name
IL-19 antibody
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Description
IL-19 Mouse Monoclonal antibody. Positive IHC detected in human tonsillitis tissue, human breast cancer tissue, human skin cancer tissue. Positive WB detected in Transfected HEK-293 cells, Recombinant protein. Observed molecular weight by Western-blot: 22 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
IL 10C antibody; IL 19 antibody; IL19 antibody; interleukin 19 antibody; MDA1 antibody; NG.1 antibody; ZMDA1 antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of IL-19 recombinant protein (Accession Number: BC153127). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS only, pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:107386(IL19 Antibody) at dilution of 1:1000
Recombinant protein were subjected to SDS PAGE followed by western blot with Catalog No:107386(IL19 Antibody) at dilution of 1:10000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:107386(IL19 Antibody) at dilution of 1:500 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:107386(IL19 Antibody) at dilution of 1:500 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
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Background
IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"