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  • IFT57 Polyclonal Antibody
  • IFT57 Polyclonal Antibody

IFT57 Polyclonal Antibody

Cat.#: 166586

Special Price 174.2 USD

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Product Information

  • Product Name
    IFT57 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to IFT57
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse
  • Alternative names
    IFT57 antibody; ESRRBL1 antibody; HIPPI antibody; MHS4R2 antibody; intraflagellar transport 57 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • Validations

    Immunohistochemistry - IFT57 Polyclonal Antibody

    Immunohistochemistry - IFT57 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded human uterine cancer using IFT57 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - IFT57 Polyclonal Antibody

    Immunohistochemistry - IFT57 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat ovary using IFT57 antibody at dilution of 1:100 (40x lens).

  • Background
    Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"