-
Product Name
IFT43 antibody
- Documents
-
Description
IFT43 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue.
-
Tested applications
ELISA, IHC
-
Species reactivity
Human; other species not tested.
-
Alternative names
C14orf179 antibody; FLJ32173 antibody; IFT43 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of IFT43 recombinant protein (Accession Number: NM_052873). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
IHC: 1:20-1:200
-
Validations
Immunohistochemistry of paraffin-embedded human testis slide using Catalog No:111668(C14orf179 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human testis slide using Catalog No:111668(C14orf179 Antibody) at dilution of 1:50 (under 40x lens)
-
Background
IFT43, encoded by C14ORF179, is a subunit of the intraflagellar transport complex A (IFT-A) of primary cilia. The IFT-A is implicated in retrograde ciliary transport along axonemal microtubules. Defects in subunits of IFT-A has been associated with skeletal ciliopathies, including Sensenbrenner syndrome, Jeune syndrome, and Ellis-van-Creveld syndrome. Mutations in C14ORF179 has been linked to Sensenbrenner syndrome. (21378380)
-
References
- Luo N, Conwell MD, Chen X. Primary cilia signaling mediates intraocular pressure sensation. Proceedings of the National Academy of Sciences of the United States of America. 111(35):12871-6. 2014.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"