IFIH1 Rabbit Polyclonal antibody. Positive IP detected in Jurkat cells. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 117-125kd
ELISA, WB, IP
Human; other species not tested.
Helicard antibody; Helicase with 2 CARD domains antibody; Hlcd antibody; IDDM19 antibody; IFIH1 antibody; MDA 5 antibody; MDA5 antibody; RH116 antibody
This antibody was obtained by immunization of IFIH1 recombinant protein (Accession Number: BC111750). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:111616(IFIH1 antibody) at dilution of 1:1500
IP Result of anti-IFIH1 (IP:Catalog No:111616, 4ug; Detection:Catalog No:111616 1:800) with Jurkat cells lysate 2400ug.
IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase.This antibody is specific to IFIH1.
- Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. The Journal of general virology. 96(Pt 1):170-82. 2015.
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