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IA-2/PTPRN antibody

Cat.#: 111580

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Product Information

  • Product Name
    IA-2/PTPRN antibody
  • Documents
  • Description
    IA-2/PTPRN Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, HEK-293 cells, mouse kidney tissue, rat brain tissue. Positive IP detected in mouse brain tissue. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 60-65kd,106-115kd
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human, Mouse, Rat; other species not tested.
  • Alternative names
    FLJ16131 antibody; IA 2 antibody; IA 2/PTP antibody; IA2 antibody; ICA 512 antibody; ICA3 antibody; ICA512 antibody; Islet cell antigen 512 antibody; Islet cell autoantigen 3 antibody; PTP IA 2 antibody; PTPRN antibody; R PTP N antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of IA-2/PTPRN recombinant protein (Accession Number: BC007713). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111580(PTPRN antibody) at dilution of 1:300

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:111580(PTPRN antibody) at dilution of 1:300

    IP Result of anti-PTPRN (IP:Catalog No:111580, 3ug; Detection:Catalog No:111580 1:600) with mouse brain tissue lysate 7000ug.

    IP Result of anti-PTPRN (IP:Catalog No:111580, 3ug; Detection:Catalog No:111580 1:600) with mouse brain tissue lysate 7000ug.

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:111580(PTPRN antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:111580(PTPRN antibody) at dilution of 1:50 (under 10x lens)

  • Background
    IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell).(PMID: 10027571). IA-2/PTPRN was found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"