Human WIPI1 Recombinant protein (GST tag)

Human WIPI1 Recombinant protein (GST tag)

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Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. {PubMed:15020712, PubMed:15602573, PubMed:20114074, PubMed:20484055, PubMed:20639694, PubMed:21317285, PubMed:22829830, PubMed:23088497}.

WD repeat domain phosphoinositide-interacting protein 1

WIPI49

Q5MNZ9

WIPI1; WIPI49

E. coli

A DNA sequence encoding the human WIPI1 (NP_060453.3) 346-446 aa was fused with the N-terminal GST tag

Human

Not tested.