Human WDR48 Recombinant protein (GST tag)

Human WDR48 Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1. {PubMed:12196293, PubMed:18082604, PubMed:19075014}.

WD repeat-containing protein 48

KIAA1449; UAF1

Q8TAF3

WDR48; KIAA1449; UAF1

E. coli

A DNA sequence encoding the human WDR48 (NP_001333154.1) 371-715 aa was fused with the N-terminal GST tag

Human

Not tested.