Human USP15 Recombinant protein (GST tag)

Human USP15 Recombinant protein (GST tag)

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Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. {PubMed:16005295, PubMed:17318178, PubMed:19553310, PubMed:19576224, PubMed:19826004, PubMed:21947082, PubMed:22344298, PubMed:24526689}.

Ubiquitin carboxyl-terminal hydrolase 15

KIAA0529

Q9Y4E8

USP15; KIAA0529

E. coli

A DNA sequence encoding the human USP15 (NP_006304.1) 1-227 aa was fused with the N-terminal GST tag

Human

Not tested.