Human UFD1L Recombinant protein (GST tag)

Human UFD1L Recombinant protein (GST tag)

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Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Ubiquitin fusion degradation protein 1 homolog

Q92890

UFD1L

E. coli

A DNA sequence encoding the human UFD1L (NP_001349839.1) 1-302 aa was fused with the N-terminal GST tag

Human

Not tested.