Human UBE2N Recombinant protein (GST tag)

Human UBE2N Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {PubMed:10089880, PubMed:14562038, PubMed:19269966, PubMed:20061386, PubMed:21512573}.

Ubiquitin-conjugating enzyme E2 N

BLU

P61088

UBE2N; BLU

E. coli

A DNA sequence encoding the human UBE2N (NP_003339.1) 1-148 aa was fused with the N-terminal GST tag

Human

Not tested.